The present manuscript describes simple, sensitive, rapid, accurate, precise and economical dual wavelength spectrophotometric method for the simultaneous determination of Doxofylline and Ambroxol Hydrochloride in pure and bulk form. All these methods utilize Distilled Water as a solvent. In Dual wavelength method, the determination of Doxofylline was carried out at the absorbance difference between 240.60 nm and 245 nm and of Ambroxol Hydrochloride at the absorbance difference between 306.60 nm and 315 nm. The results of analysis have been validated statistically. The proposed methods were found to be simple and sensitive for the routine quality control application of Doxofylline and Ambroxol Hydrochloride in pure and bulk form. The results were found to be within acceptance criteria according to ICH Q2 R1 guideline.
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